Motif ID: FOX{F1,F2,J1}.p2

Z-value: 1.688


Transcription factors associated with FOX{F1,F2,J1}.p2:

Gene SymbolEntrez IDGene Name
FOXF1 2294 forkhead box F1
FOXF2 2295 forkhead box F2
FOXJ1 2302 forkhead box J1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXJ1chr17_-_741373700.647.2e-03Click!
FOXF1chr16_+_86544104-0.292.8e-01Click!
FOXF2chr6_+_1390068-0.273.1e-01Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_161193190 8.796 APOA2
apolipoprotein A-II
chr1_-_161193375 8.260 NM_001643
 APOA2
apolipoprotein A-II
chr4_+_74269971 5.459 NM_000477
 ALB
albumin
chr22_+_21128378 5.001 NM_000185
 SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr4_+_155484131 4.419 NM_001184741
NM_005141
 FGB

fibrinogen beta chain

chr4_+_74270832 4.246 ALB
albumin
chr4_+_100495972 4.074 MTTP
microsomal triglyceride transfer protein
chr17_-_7082559 4.068 ASGR1
asialoglycoprotein receptor 1
chr17_-_7082654 3.359 NM_001197216
NM_001671
 ASGR1

asialoglycoprotein receptor 1

chr14_-_94789641 3.255 NM_001756
 SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr7_-_87342569 3.204 NM_000927
 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_169555624 3.089 F5
coagulation factor V (proaccelerin, labile factor)
chr9_-_116840545 3.026 AMBP
alpha-1-microglobulin/bikunin precursor
chr1_+_207277577 3.022 NM_000715
 C4BPA
complement component 4 binding protein, alpha
chr6_-_41715078 2.999 NM_001166424
NM_002630
 PGC

progastricsin (pepsinogen C)

chr12_-_63328857 2.983 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr7_+_134832765 2.978 NM_018295
 TMEM140
transmembrane protein 140
chr10_-_52645384 2.904 A1CF
APOBEC1 complementation factor
chr14_+_95078713 2.866 NM_001085
 SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_+_72427535 2.856 NM_022036
 GPRC5C
G protein-coupled receptor, family C, group 5, member C

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
Enrichment   P-value GO Accession GO Term
93.70 1.47e-03 GO:0030300 regulation of intestinal cholesterol absorption
66.93 5.08e-03 GO:0010873 positive regulation of cholesterol esterification
58.57 8.09e-03 GO:0010872 regulation of cholesterol esterification
46.86 1.72e-02 GO:0034374 low-density lipoprotein particle remodeling
39.05 3.12e-02 GO:0034377 plasma lipoprotein particle assembly
39.05 3.12e-02 GO:0044058 regulation of digestive system process
39.05 3.12e-02 GO:0065005 protein-lipid complex assembly
29.75 5.00e-03 GO:0034367 macromolecular complex remodeling
29.75 5.00e-03 GO:0034368 protein-lipid complex remodeling
29.75 5.00e-03 GO:0034369 plasma lipoprotein particle remodeling
25.00 1.04e-02 GO:0071825 protein-lipid complex subunit organization
25.00 1.04e-02 GO:0071827 plasma lipoprotein particle organization
20.56 2.34e-03 GO:0030301 cholesterol transport
20.03 2.67e-03 GO:0015918 sterol transport
18.38 3.64e-02 GO:0097006 regulation of plasma lipoprotein particle levels
18.17 4.38e-03 GO:0042632 cholesterol homeostasis
18.17 4.38e-03 GO:0055092 sterol homeostasis
17.86 4.09e-02 GO:0008206 bile acid metabolic process
16.74 8.28e-04 GO:0010951 negative regulation of endopeptidase activity
16.17 1.02e-03 GO:0055088 lipid homeostasis

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
Enrichment   P-value GO Accession GO Term
26.04 2.18e-02 GO:0034361 very-low-density lipoprotein particle
26.04 2.18e-02 GO:0034385 triglyceride-rich lipoprotein particle
18.03 1.03e-04 GO:0031983 vesicle lumen
16.62 1.33e-03 GO:0031093 platelet alpha granule lumen
16.28 1.47e-03 GO:0034774 secretory granule lumen
15.63 1.80e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
13.95 3.16e-03 GO:0031091 platelet alpha granule
6.08 1.68e-02 GO:0030141 stored secretory granule
3.53 1.90e-03 GO:0005615 extracellular space
3.00 7.25e-03 GO:0044421 extracellular region part
2.42 6.48e-03 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
Enrichment   P-value GO Accession GO Term
156.16 3.62e-05 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
156.16 5.82e-03 GO:0047026 androsterone dehydrogenase (A-specific) activity
156.16 5.82e-03 GO:0047718 indanol dehydrogenase activity
117.12 1.44e-04 GO:0047023 androsterone dehydrogenase activity
104.11 1.74e-02 GO:0004873 asialoglycoprotein receptor activity
104.11 1.74e-02 GO:0034190 apolipoprotein receptor binding
104.11 1.74e-02 GO:0070653 high-density lipoprotein particle receptor binding
62.47 4.53e-05 GO:0017127 cholesterol transporter activity
52.06 1.06e-04 GO:0015248 sterol transporter activity
33.47 1.25e-02 GO:0070325 lipoprotein particle receptor binding
22.32 4.43e-02 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
17.64 1.76e-05 GO:0004867 serine-type endopeptidase inhibitor activity
13.71 4.34e-03 GO:0005319 lipid transporter activity
12.81 6.05e-03 GO:0005496 steroid binding
9.69 1.07e-03 GO:0004866 endopeptidase inhibitor activity
9.52 1.20e-03 GO:0030414 peptidase inhibitor activity
9.28 1.42e-03 GO:0061135 endopeptidase regulator activity
7.66 4.95e-03 GO:0061134 peptidase regulator activity
5.64 1.19e-02 GO:0004857 enzyme inhibitor activity
4.33 1.39e-02 GO:0008289 lipid binding